The American College of Cardiology’s 2022 meeting included live case broadcasts from the Piedmont Heart Institute at Piedmont Atlanta Hospital. This live case, performed by interventional cardiologists Dr. Prashant Kaul and Dr. David Kandzari, featured a 60-year-old patient, newly diagnosed with diabetes who was experiencing worsening exertional chest pain. The case discussion focuses on the treatment algorithm for calcified lesions. Throwing a curveball into the live case: the patient tested positive for COVID-19 during routine screening the night before. “This added another dimension to the case, but given the disease severity we felt it was reasonable to proceed,” Dr. Kaul said.